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Anti-PEG antibodies enriched within the protein corona of PEGylated nanocarriers influence the cell uptake


Poly(ethylene glycol) (PEG) is the gold commonplace used to scale back unspecific protein adsorption and lengthen nanocarrier circulation time. Nevertheless, this stealth impact might be counteracted by the growing prevalence of anti-PEG antibodies within the bloodstream. Thus far, the presence of anti-PEG antibodies within the protein corona and their impact on cell uptake has not been investigated but. Our outcomes confirmed a excessive focus and prevalence of anti-PEG antibodies within the German inhabitants. PEGylated nanocarriers exhibited the next stage of anti-PEG antibodies within the protein corona in comparison with non-PEGylated, which result in larger uptake in macrophages. Consequently, the anti-PEG antibodies within the protein corona may mitigate the stealth impact of PEG, resulting in accelerated blood clearance and undesirable unintended effects.

Graphical abstract: Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake

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