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Monday, April 15, 2024

Particular interplay primarily based drug loading methods

Drug carriers have been generally used for drug management launch, enhancing drug efficacy and/or minimizing side-effects. Nonetheless, it’s nonetheless troublesome to get a excessive loading effectivity when encapsulating tremendous hydrophilic medication with a slender therapeutic index, equivalent to many neurotoxins. Rising the provider proportion can enhance drug loading to a sure diploma, whereas the burst launched drug when the formulation enters the physique might trigger overdose side-effects. Furthermore, high-dose carriers themselves might improve the metabolic burden of the physique. Therefore, new drug carriers and/or loading methods are urgently wanted to advertise the functions of those medication. This minireview will introduce drug loading methods primarily based on particular interactions (between medication and carriers) and can talk about the challenges and views of those methods. This work is anticipated to offer various inspiration for the supply of hydrophilic medication.

Graphical abstract: Specific interaction based drug loading strategies

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